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Treatment effect estimates (chemoimmunotherapy versus chemotherapy) with continuous BMI by the method of <t>Multivariate</t> <t>Fractional</t> <t>Polynomial</t> Interaction with Cox proportional-hazard regression models stratified by trial for overall survival ( a ) and progression-free survival ( b ). The shaded area is the 95% CIs of the treatment effect estimated as hazard ratios (HRs) (black solid line). Vertical dotted lines mark the 5 th and 95 th percentile of BMI distribution of the pooled analysis cohort, at 19.8 kg/m 2 and 34.7 kg/m 2 respectively
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Treatment effect estimates (chemoimmunotherapy versus chemotherapy) with continuous BMI by the method of Multivariate Fractional Polynomial Interaction with Cox proportional-hazard regression models stratified by trial for overall survival ( a ) and progression-free survival ( b ). The shaded area is the 95% CIs of the treatment effect estimated as hazard ratios (HRs) (black solid line). Vertical dotted lines mark the 5 th and 95 th percentile of BMI distribution of the pooled analysis cohort, at 19.8 kg/m 2 and 34.7 kg/m 2 respectively

Journal: BMC Cancer

Article Title: A lack of association between BMI and chemoimmunotherapy efficacy in advanced non-small cell lung cancer: Secondary analysis of the IMpower150 and IMpower130 clinical trials

doi: 10.1186/s12885-024-12132-w

Figure Lengend Snippet: Treatment effect estimates (chemoimmunotherapy versus chemotherapy) with continuous BMI by the method of Multivariate Fractional Polynomial Interaction with Cox proportional-hazard regression models stratified by trial for overall survival ( a ) and progression-free survival ( b ). The shaded area is the 95% CIs of the treatment effect estimated as hazard ratios (HRs) (black solid line). Vertical dotted lines mark the 5 th and 95 th percentile of BMI distribution of the pooled analysis cohort, at 19.8 kg/m 2 and 34.7 kg/m 2 respectively

Article Snippet: Continuous BMI was modelled in stratified (by RCT) Cox proportional hazards regression by the method of (Multivariable) Fractional Polynomial Interaction (MFPI) [ ].

Techniques: